Mouse Neuropilin-1, NRP1 ELISA Kit

SKU: E1019Mo

Size:96 Tests-1 Kit

Background:Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (PubMed: 26503042). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (By similarity). Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed: 26503042). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:NRP1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Neuropilin-1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P97333

MASS(Da):103,000

GeneID:18186

Synonyms:A5 protein;CD antigen CD304;Neuropilin-1;NRP 1;NRP1

Gene names:NRP1

Standard solution:16ng/ml