Mouse Mitochondrial Brown Fat Uncoupling Protein 1, UCP1 ELISA Kit

SKU: E2262Mo

Size:96 Tests-1 Kit

Background:Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (PubMed: 9139827, PubMed: 19187776, PubMed: 23063128, PubMed: 27027295). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP (PubMed: 23063128). Regulates the production of reactive oxygen species/ROS by mitochondria (PubMed: 20416274, PubMed: 20466728).

Research_area:Cancer

Applications:ELISA

Target_protein:UCP1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.27ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Mitochondrial Brown Fat Uncoupling Protein 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P12242

MASS(Da):33,248

GeneID:22227

Synonyms:Mitochondrial brown fat uncoupling protein 1;Solute carrier family 25 member 7;Thermogenin;UCP 1;UCP1

Gene names:UCP1

Standard solution:6400ng/L