Mouse MFGE8 / Lactadherin / Milk Fat Globule 1 ELISA Kit PicoKine®

SKU: EK1194

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: MFGE8

Specificity: Natural and recombinant mouse MFGE8

Background: MFGE8 (Milk Fat Globule-Egf Factor 8), also called as Lactadherin or SED1, is a protein which in humans is encoded by the MFGE8 gene. Mfge8 is secreted protein found in vertebrates, including mammals as well as birds. By fluorescence in situ hybridization, the MFGE8 gene was mapped to chromosome 15q25. MFGE8 is a factor that links apoptotic cells to phagocytes. It specifically bound to apoptotic cells by recognizing aminophospholipids such as phosphatidylserine. MFGE8, when engaged by phospholipids, bound to cells via its RGD motif. It bound particularly strongly to cells expressing alpha-V-beta-3 integrin. It showed that Mfge8 was expressed in intestinal lamina propria macrophages in mice. Using a wound-healing assay, they showed that Mfge8 promoted migration of intestinal epithelial cells through a PKC-epsilon (PRKCE)-dependent mechanism.

Immunogen: Expression system for standard: NS0; Immunogen sequence: A23-C463

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Reference:

Uniprot ID: P21956

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 17304

Protein Name: Lactadherin

Gene Full Name: milk fat globule EGF and factor V/VIII domain containing

Synonyms: BA46; Breast epithelial antigen BA46; EDIL1; HMFG; hP47; HsT19888; Lactadherin; MFG E8; MFGE8; MFG-E8; MFGM; Milk fat globule EGF factor 8; OAcGD3S; SED1; SPAG10