Mouse Legumain(total) ELISA Kit PicoKine®

SKU: EK1567

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: Lgmn

Specificity: Natural and recombinant mouse Legumain(total)

Background: Legumain (asparaginyl endopeptidase, citvac, proteinase B, hemoglobinase, PRSC1 gene product or LGMN (Homo sapiens), vicilin peptidohydrolase, bean endopeptidase) is an enzyme that in humans is encoded by the LGMN gene (previous symbolPRSC1). Using fluorescence in situ hybridization, the LGMN gene was mapped to chromosome 14q32.1. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types.

Immunogen: Expression system for standard: NS0; Immunogen sequence: V18-Y435

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Reference:

Uniprot ID: O89017

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 19141

Protein Name: Legumain

Gene Full Name: legumain

Synonyms: AEP; cysteine 1; Legumain; LGMN; LGMN1; PRSC1