Mouse Interleukin-36 Alpha, IL1F6 ELISA Kit

SKU: E2191Mo

Size:96 Tests-1 Kit

Background:Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T-cell proliferation. Induces NF-kappa B activation in macrophages.

Research_area:Immunology

Applications:ELISA

Target_protein:IL36A

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:3.13ng/L

Detection range:6-1800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin-36 Alpha

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9JLA2

MASS(Da):18,015

GeneID:54448

Synonyms:FIL1 epsilon;IL 36A;IL-1 epsilon;IL-1F6;IL-1H1;IL36A;Interleukin-1 epsilon;Interleukin-1 family member 6;Interleukin-1 homolog 1;Interleukin-36 alpha

Gene names:IL36A

Standard solution:1920ng/L