Mouse Interleukin 11, IL-11 ELISA Kit

SKU: E0021Mo

Size:96 Tests-1 Kit

Background:Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed: 8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed: 22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed: 10026196, PubMed: 23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed: 23948300, PubMed: 22253262). The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (By similarity).

Research_area:Immunology

Applications:ELISA

Target_protein:IL11

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.43ng/L

Detection range:1-300ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin 11

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P47873

MASS(Da):21,522

GeneID:16156

Synonyms:IL 11;IL11;IL-11;Interleukin-11

Gene names:IL11

Standard solution:320ng/L