Mouse Interleukin 1 Receptor 1,IL1R1 ELISA KIT

SKU: E2665Mo

Size:96 Tests-1 Kit

Background:Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity). {ECO:0000250|UniProtKB:P14778}.; [Isoform 2]: Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation. {ECO:0000269|PubMed:22778412}.

Research_area:

Applications:ELISA

Target_protein:Il1r1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:7.19ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin 1 Receptor 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P13504

MASS(Da):66698

GeneID:16177

Synonyms:Il1r1 Il-1r1 Il1ra

Gene names:Il1r1

Standard solution:3200ng/L