Mouse Hydroxycarboxylic acid receptor 2,Hcar2 ELISA KIT

SKU: E0985Mo

Size:96 Tests-1 Kit

Background:Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. {ECO:0000269|PubMed:15929991}.

Research_area:

Applications:ELISA

Target_protein:Hcar2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Hydroxycarboxylic acid receptor 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9EP66

MASS(Da):41401

GeneID:80885

Synonyms:Hcar2 Gpr109 Gpr109a Gpr109b Niacr1 Pumag

Gene names:Hcar2

Standard solution:24ng/ml