Mouse Heat Shock 70kDa Protein 5,HSPA5 ELISA KIT

SKU: E0872Mo

Size:96 Tests-1 Kit

Background:Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:12411443, PubMed:12475965). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (PubMed:12411443). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P11021, ECO:0000269|PubMed:12411443, ECO:0000269|PubMed:12475965}.

Research_area:

Applications:ELISA

Target_protein:Hspa5

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.107ng/ml

Detection range:0.2-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Heat Shock 70kDa Protein 5

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P20029

MASS(Da):72422

GeneID:14828

Synonyms:Hspa5 Grp78

Gene names:Hspa5

Standard solution:64ng/ml