Mouse glucocorticoid receptor,Nr3c1 ELISA KIT

SKU: E0659Mo

Size:96 Tests-1 Kit

Background:Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:10678832, ECO:0000269|PubMed:15037546}.; [Isoform 1]: Has transcriptional activation and repression activity (By similarity). Mediates glucocorticoid-induced apoptosis (By similarity). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (PubMed:21994940). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:21994940, ECO:0000269|PubMed:25847991}.; [Isoform 3]: Acts as a dominant negative inhibitor of isoform 1 (PubMed:20660300). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (By similarity). Loses this transcription modulator function on its own (By similarity). Has no hormone-binding activity (PubMed:20660300). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (PubMed:20660300). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (By similarity). Directly regulates STAT1 expression in isoform Alpha-independent manner (By similarity). {ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:20660300}.

Research_area:

Applications:ELISA

Target_protein:Nr3c1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:2.82pg/ml

Detection range:5-320pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:glucocorticoid receptor

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P06537

MASS(Da):87164

GeneID:

Synonyms:Nr3c1 Grl Grl1

Gene names:Nr3c1

Standard solution:640pg/ml