Mouse G-CSF/CSF3 EZ-Set™ ELISA Kit (DIY Antibody Pairs)

SKU: EZ0361

Size: 5 plates/kit

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: CSF3

Specificity: Natural and recombinant mouse G-CSF

Background: Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of hormone-like glycoprotein that regulates hematopoietic cell proliferation and differentiation, and it almost exclusively stimulates the colony formation of granulocytes from committed precursor cells in semi-solid agar culture. G-CSF is also termed colony stimulating factor-3, and a single gene of which codes for a 177 or 180 amino acid mature protein of molecular weight 19,600. Functionally, it specifically stimulates the proliferation and differentiation of the progenitor cells for granulocytes. The effect of G-CSF on myeloid leukemias is unique among colony stimulating factors in driving the leukemic cells from a self-renewing malignant state to a mature differentiated phenotype with the concomitant loss of tumorigenicity. Besides, it also prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. The recombinant form of hG-CSF is capable of supporting neutrophil proliferation in a CFU-GM assay as well as early erythroid colonies and mixed colony formation. Human gene coding for G-CSF is assigned to the q21-q22 region of chromosome 17.3 The standard product used in this kit is recombinant Mouse G-csf, consisting of 179 amino acids with the molecular mass of 19KDa.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: V31-A208

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Uniprot ID: P09920

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 12985

Protein Name: Granulocyte colony-stimulating factor

Gene Full Name: colony stimulating factor 3 (granulocyte)

Synonyms: C17orf33; CSF3; Filgrastim; G CSF; GCSF; G-CSF; Lenograstim; Pluripoietin