Mouse Ectonucleotide pyrophosphatase;phosphodiesterase family member 2,ENPP2;Autotaxin2 ELISA KIT

SKU: E2698Mo

Size:96 Tests-1 Kit

Background:Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:17208043, PubMed:28414242, PubMed:27780639). Major substrate is lysophosphatidylcholine (PubMed:17208043, PubMed:27780639). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:18175805). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition (By similarity). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). {ECO:0000250|UniProtKB:Q13822, ECO:0000269|PubMed:17208043, ECO:0000269|PubMed:18175805, ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:27780639, ECO:0000269|PubMed:28414242, ECO:0000305|PubMed:15700135}.

Research_area:

Applications:ELISA

Target_protein:Enpp2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:3.87ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ectonucleotide pyrophosphatase;phosphodiesterase family member 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9R1E6

MASS(Da):98885

GeneID:18606

Synonyms:Enpp2 Npps2 Pdnp2

Gene names:Enpp2

Standard solution:1600ng/L