Mouse DMP-1 ELISA Kit PicoKine®

SKU: EK1290

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: DMP1

Specificity: Natural and recombinant mouse DMP-1

Background: Dentin matrix acidic phosphorprotein 1 is a protein that in humans is encoded by the DMP1 gene. It belongs to the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of secreted phosphoproteins. This gene is mapped to 4q22.1. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts, DMP-1 is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation, the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals.

Immunogen: Expression system for standard: NS0; Immunogen sequence: L17-Y503

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Reference:

Uniprot ID: O55188

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 13406

Protein Name: Dentin matrix acidic phosphoprotein 1

Gene Full Name: dentin matrix protein 1

Synonyms: dentin matrix acidic phosphoprotein 1; ARHP; ARHR; DMP1