Mouse CHIT1 EZ-Set™ ELISA Kit (DIY Antibody Pairs)

SKU: EZ2033

Size: 5 plates/kit

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: Chit1

Specificity: Natural and recombinant mouse CHIT1

Background: Chitotriosidase encoded by the CHIT1 gene is a member of the chitinase family that is selectively expressed in activated tissue macrophages. This gene is mapped to 1; 1 E4. It is distinct from another member known as acidic mammalian chitinase (AMC), encoded by the CHIA gene, in several aspects. AMC/CHIA is expressed mainly in alveolar macrophages and in both the mouse and human gastrointestinal tract. CHIT1, however, is expressed exclusively by phagocytes in humans and in the gastrointestinal tract, tongue, fore-stomach, and Paneth cells of the small intestine in mice. Both CHIA and CHIT1 are secreted as 50 kDa proteins. In contrast to CHIA, CHIT1 is not stable under acidic pH and can be processed into a C-terminally truncated 39 kDa form. Human CHIT1 is the best of three biomarkers in the monitoring of Gaucher disease. The other two commonly used markers include acid phosphatase and angiotensin-converting enzyme. Human CHIT1 is also a specific marker of macrophage activation in acute ischemic stroke.

Immunogen: Expression system for standard: NS0; Immunogen sequence: A22-S464

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Reference:

Uniprot ID: Q9D7Q1

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 71884

Protein Name: Chitotriosidase-1

Gene Full Name: chitinase 1

Synonyms: CHI3; CHIT; CHIT1; Chitinase 1; chitinase 1 (chitotriosidase); Chitotriosidase 1