Mouse Cerebellin-1, CBLN1 ELISA Kit

SKU: E1928Mo

Size:96 Tests-1 Kit

Background:Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses (PubMed: 16234806). Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components (PubMed: 20395510). On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2 (PubMed: 21410790). NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles (PubMed: 23141067). Required for CBLN3 export from the endoplasmic reticulum and secretion (PubMed: 17030622, PubMed: 17331201). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (PubMed: 29691328). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (PubMed: 24467251). The cerebellin Peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:CBLN1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:1.63ng/L

Detection range:3-900ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cerebellin-1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9R171

MASS(Da):21,113

GeneID:12404

Synonyms:[des-Ser1]-cerebellin;Brain protein D3;CBLN 1;CBLN1;CER;Cerebellin;Cerebellin-1;des-Ser1-cerebellin;Precerebellin;

Gene names:CBLN1

Standard solution:960ng/L