Mouse ADAM12 ELISA Kit PicoKine®

SKU: EK1294

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: ADAM12

Specificity: Natural and recombinant mouse ADAM12

Background: ADAM12 (Disintegrin and metalloproteinase domain-containing protein 12), also known as MLTN, is an enzyme that in humans is encoded by the ADAM12 gene. This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis. By RT-PCR and immunoblot analyses that expression of mouse Adam12 increases during muscle regeneration, while the levels of other ADAMs remain constant. Immunofluorescence analysis revealed staining of small, newly formed muscle fibers in regenerating but not normal adult muscle cells. By using of fluorescence in situ hybridization, the ADAM12 gene is mapped to human chromosome 10q26.3.

Immunogen: Expression system for standard: NS0; Immunogen sequence: E206-G706

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Reference:

Uniprot ID: Q61824

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 11489

Protein Name: Disintegrin and metalloproteinase domain-containing protein 12

Gene Full Name: ADAM metallopeptidase domain 12

Synonyms: ADAM 12; ADAM12; MCMP; MCMPMltna; Meltrin alpha; MLTN; MLTNA