MLKL (phospho Ser358) rabbit pAb

SKU: ES14935

Size: 100μL

Source:Rabbit

Applications:IHC;IF;WB

Reactivity:Human

Dilution:IHC-p 1:100-500;IF/ICC 1:100-500;WB 1:500-2000

Immunogen:Synthesized peptide derived from human MLKL (phospho S358)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):55kD

Human_gene_id:197259

Human_swiss_prot_no:Q8NB16

Subcellular_location:Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .

Other_name:Mixed lineage kinase domain-like protein

Background:This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],