Metadherin Monoclonal Antibody

SKU: BT-MCA4538

Size:100μL

Background:Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Research_area:Others

Target_protein:Metadherin

applications:WB, IHC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2F11C3

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:Metadherin

Immunogen:Purified recombinant fragment of human Metadherin expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):64kDa

UniProt accession:Q86UE4

Synonyms:3D3, AEG1, LYRIC, MTDH

GeneID:92140