MER Monoclonal Antibody

SKU: BT-MCA2823

Size:100μL

Background:MER (c-mer proto-oncogene tyrosine kinase) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MER has been identified as a tyrosine kinase potentially involved in the development of glioblastomas. It is expressed at highest levels in ovary, prostate, lung and kidney. Gas6, a growth arrest specific gene, and the related anticoagulation factor Protein S have been identified as ligands for the UFO family of receptors. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Research_area:Others

Target_protein:MER

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:7E5G1

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MER

Immunogen:Purified recombinant fragment of MER expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:Q12866

Synonyms:MER, RP38, c-mer, MGC133349, MERTK

GeneID:10461