MDC1 Antibody - Cat. #: CSB-PA098783

SKU: CSB-PA098783

Size :50ul

Clone Number:

Aliases:Homologue to Drosophila photoreceptor protein calphotin antibody; MDC 1 antibody; Mdc1 antibody; MDC1_HUMAN antibody; Mediation of DNA damage checkpoint 1 antibody; Mediator of DNA damage checkpoint 1 antibody; Mediator of DNA damage checkpoint protein 1 antibody; NFBD 1 antibody; NFBD1 antibody; Nuclear factor with BRCT domains 1 antibody; Nuclear Factor with BRCT Domains Protein 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q14676

Immunogen:Synthetic peptide of Human MDC1

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; ELISA:1:2000-1:10000, IHC:1:100-1:300

Background:The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MDC1

Research Areas:Epigenetics and Nuclear Signaling