MCM3AP Monoclonal Antibody

SKU: BT-MCA3552

Size:100μL

Background:The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability.

Research_area:Cell Biology

Target_protein:MCM3AP

applications:

Reactivity:

Clonality:Monoclonal

Clone ID:5B2C4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MCM3AP

Immunogen:Purified recombinant fragment of human MCM3AP (AA: 293-442) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):218.4kDa

UniProt accession:O60318

Synonyms:GANP, SAC3, MAP80, PNRIID

GeneID:8888