MCM3AP Antibody - Cat. #: CSB-PA243490

SKU: CSB-PA243490

Size :100ul

Clone Number:

Aliases:80 kDa MCM3 associated protein antibody; 80 kDa MCM3-associated protein antibody; FLJ44336 antibody; FLJ45306 antibody; Germinal center associated nuclear protein antibody; KIAA0572 antibody; MAP80 antibody; MCM3 import protein antibody; MCM3 minichromosome maintenance deficient 3 associated protein antibody; MCM3A antibody; MCM3A_HUMAN antibody; Mcm3ap antibody; Minichromosome maintenance complex component 3 associated protein antibody; Minichromosome maintenance deficient 3 associated protein antibody; Minichromosome maintenance protein 3 associated protein antibody; Protein GANP antibody; SAC3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O60318

Immunogen:Synthesized peptide derived from Human GANP.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

Background:Isoform GANP:Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP:Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.

Nobuo Sakaguchi, J. Immunol., Apr 2005; 174: 4485 - 4494.
Kazuhiko Kuwahara, Blood, Apr 2000; 95: 2321 - 2328.
Y Kono, K Maeda, Genes Cells, Aug 2002; 7: 821 - 834.
Kazuhiko Kuwahara, PNAS, Aug 2001; 98: 10279.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MCM3AP

Research Areas:Epigenetics and Nuclear Signaling;Cell biology