MASP1 Rabbit Polyclonal Antibody

SKU: BT-AP03542

Size:100μL

Background:enzyme regulation:Inhibited by SERPING1 and A2M.|Functions in the lectin pathway of complement| which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.|PTM:Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond. Isoform 1 but not isoform 2 is activated through autoproteolytic processing.|PTM:N-glycosylated. Some N-linked glycan are of the complex-type.|PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.|Belongs to the peptidase S1 family.|Contains 1 EGF-like domain.|Contains 1 peptidase S1 domain.|Contains 2 CUB domains.|Contains 2 Sushi (CCP/SCR) domains.|subunit:Homodimer. Interacts with the oligomeric lectins MBL2| FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1.|tissue specificity:Protein of the plasma which is primarily expressed by liver.|

Research_area:Immunology

Target_protein:MASP1

applications:WB, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:MASP1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):76890

UniProt accession:Human: P48740; Mouse: P98064; Rat: Q8CHN8

Synonyms:MASP1 ;light chain; Cleaved-Ile449; Mannan-binding lectin serine protease 1; EC 3.4.21.-; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease 1; MASP-1; Mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain;

GeneID:Human: 5648; Mouse: 17174; Rat: 64023