MARK1 Antibody - Cat. #: CSB-PA219426

SKU: CSB-PA219426

Size :100ul

Clone Number:

Aliases:KIAA1477 antibody; MAP/microtubule affinity regulating kinase 1 antibody; MAP/microtubule affinity-regulating kinase 1 antibody; MARK 1 antibody; MARK antibody; Mark1 antibody; MARK1_HUMAN antibody; MGC126512 antibody; MGC126513 antibody; Serine/threonine protein kinase MARK1 antibody; Serine/threonine-protein kinase MARK1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9P0L2

Immunogen:Synthesized peptide derived from internal of Human MARK.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Lizcano J.M., EMBO J. 23:833-843(2004).
Nagase T., DNA Res. 7:143-150(2000).
Gregory S.G., Nature 441:315-321(2006).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MARK1

Research Areas:Signal transduction