MAP2K6 (Ab-207) Antibody - Cat. #: CSB-PA957863

SKU: CSB-PA957863

Size :100ul

Clone Number:

Aliases:Dual specificity mitogen activated protein kinase kinase 6 antibody; Dual specificity mitogen-activated protein kinase kinase 6 antibody; MAP kinase kinase 6 antibody; MAP2K6 antibody; MAPK/ERK kinase 6 antibody; MAPKK 6 antibody; MAPKK6 antibody; MEK 6 antibody; MEK6 antibody; Mitogen Activated Protein Kinase Kinase 6 antibody; MKK 6 antibody; MKK6 antibody; MP2K6_HUMAN antibody; PRKMK6 antibody; protein kinase antibody; Protein kinase mitogen activated kinase 6 antibody; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6) antibody; SAPK kinase 3 antibody; SAPKK-3 antibody; SAPKK3 antibody; SKK3 antibody; Stress-activated protein kinase kinase 3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P52564

Immunogen:Peptide sequence around aa.205~209 (V-D-S-V-A) derived from Human MKK6.

Raised in:Rabbit

Species Reactivity:Human, Rat

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

Background:

MEK6 is a member of MAPKK protein kinase family. By using degenerate oligonucleotide primers from the conserved kinase domains of MKK3 and MKK4 two human cDNAs and 1 murine cDNA encoding closely related proteins of the MKK family were cloned. The two human clones appear to be different isoforms of the same gene generated by differential splicing: the shorter clone was designated MKK6, encodes a 278-amino acid protein, while the longer clone, designated MKK6b, encodes a 334-amino acid protein. MKK6 is about 80% identical to MKK3 and 40% identical to MKK4. 1.7-kb human MKK6 transcript is highly expressed in skeletal muscle, while an MKK6b-specific probe detected mRNA bands of 1.8, 2.4, and 4.5 kb that are enriched in heart, skeletal muscle, pancreas and liver. MKK6 plays an important role in intracellular signaling pathways leading toward activation of the p38 MAP kinase . MEK6 phosphorylates and activates p38 in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAPK mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

Wang W, et al. (2002) Mol Cell Biol ; 22(10): 3389-403.
Raingeaud J, et al. (1996) Mol Cell Biol; 16(3): 1247-55.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MAP2K6

Research Areas:Cell biology;Immunology;Signal transduction