LT-β rabbit pAb

SKU: ES8728

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Human;Rat;Mouse;

Dilution:IHC-p 1:50-200, ELISA 1:10000-20000,WB 1:500-2000

Immunogen:Synthetic peptide from human protein at AA range: 41-90

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:4050

Human_swiss_prot_no:Q06643

Subcellular_location:Membrane ; Single-pass type II membrane protein .

Other_name:Lymphotoxin-beta (LT-beta;Tumor necrosis factor C;TNF-C;Tumor necrosis factor ligand superfamily member 3)

Background:Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],