LMNA Monoclonal Antibody

SKU: BT-MCA4638

Size:100μL

Background:The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Research_area:Tags & Cell Markers

Target_protein:LMNA

applications:WB, IHC

Reactivity:Human, Mouse, Rat

Clonality:Monoclonal

Clone ID:4E7

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:LMNA

Immunogen:Purified recombinant fragment of human LMNA expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):74kDa

UniProt accession:P02545

Synonyms:FPL, IDC, LFP, CDDC, EMD2, FPLD, HGPS, LDP1, LMN1, LMNC, PRO1, CDCD1, CMD1A, FPLD2, LMNL1, CMT2B1

GeneID:4000