LDLRAP1 Antibody - Cat. #: CSB-PA729190ESR1HU

SKU: CSB-PA729190ESR1HU

Size :50ul

Clone Number:

Aliases:ARH antibody; ARH GENE antibody; ARH_HUMAN antibody; ARH1 antibody; ARH2 antibody; Autosomal recessive hypercholesterolemia protein antibody; DKFZp586D0624 antibody; FHCB1 antibody; FHCB2 antibody; LDL receptor adaptor protein antibody; Ldlrap1 antibody; Low density lipoprotein receptor adapter protein 1 antibody; MGC34705 antibody; OTTHUMP00000008526 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q5SW96

Immunogen:Recombinant Human Low density lipoprotein receptor adapter protein 1 protein (59-308AA)

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background:Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:LDLRAP1

Research Areas:Cardiovascular; Metabolism; Signal transduction