LAMTOR1 Antibody, FITC conjugated - Cat. #: CSB-PA757083LC01HU

SKU: CSB-PA757083LC01HU

Size :50ug

Clone Number:

Aliases:C11orf59 antibody; LAMTOR1 antibody; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 antibody; Lipid raft adaptor protein p18 antibody; LTOR1_HUMAN antibody; p18 antibody; p27Kip1-releasing factor from RhoA antibody; p27RF-Rho antibody; PDRO antibody; PP7157 antibody; Protein associated with DRMs and endosomes antibody; Ragulator complex protein LAMTOR1 antibody; ragulator complex protein PDRO antibody; Ragulator1 antibody; RhoA activator C11orf59 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q6IAA8

Immunogen:Recombinant Human Ragulator complex protein LAMTOR1 protein (2-161AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:LAMTOR1

Research Areas:Cardiovascular; Metabolism; Signal transduction