KLHL13 Monoclonal Antibody

SKU: BT-MCA4530

Size:100μL

Background:KLHL13 (kelch-like 13), also known as BKLHD2 (BTB and kelch domain-containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate- specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.

Research_area:Epigenetics and nuclear signaling, Cell biology

Target_protein:KLHL13

applications:WB, IHC, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:8D1

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:KLHL13

Immunogen:Purified recombinant fragment of human KLHL13 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):74kDa

UniProt accession:Q9P2N7

Synonyms:BKLHD2, FLJ10262, MGC74791, KLHL13

GeneID:90293