KDM3B Polyclonal Antibody

SKU: E-AB-11339

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:KDM3B

Target Synonym:5qNCA;C5orf7;JHDM2B;JmjC domain containing histone demethylation protein 2B;JmjC domain-containing histone demethylation protein 2B;jmjd1b;Jumonji domain containing 1B;Jumonji domain containing protein 1B;Jumonji domain-containing protein 1B;KDM3B;KDM3B;KIAA1082;Lysine (K) specific demethylase 3B;Lysine-specific demethylase 3B;NET22;Nuclear protein 5qNCA

Research Areas:Cancer;Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q7LBC6

Accession:

Background:JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.

Concentration:0.4 mg/mL

Immunogen:Recombinant protein of human KDM3B

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:WB 1:1000-1:5000;IHC 1:50-1:200

Calculated MW:192kDa

ObservedMW: