ITGA5 (heavy chain, Cleaved-Arg894) rabbit pAb

SKU: ES20006

Size: 100μL

Source:Rabbit

Applications:WB;ELISA;IHC

Reactivity:Human;Mouse

Dilution:WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Immunogen:Synthesized peptide derived from human ITGA5 (heavy chain, Cleaved-Arg894)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):94 110kD

Human_gene_id:3678

Human_swiss_prot_no:P08648

Subcellular_location:Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface .

Other_name:Integrin alpha-5 (CD49 antigen-like family member E;Fibronectin receptor subunit alpha;Integrin alpha-F;VLA-5;CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]

Background:function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,