IRF-3 (phospho Ser386) rabbit pAb

SKU: ES5922

Size: 100μL

Source:Rabbit

Applications:WB;IHC

Reactivity:Human;Rat;Mouse;

Dilution:WB 1:500-2000;IHC-p 1:50-300

Immunogen:The antiserum was produced against synthesized peptide derived from human IRF-3 around the phosphorylation site of Ser386. AA range:352-401

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):48-55kd

Human_gene_id:3661

Human_swiss_prot_no:Q14653

Subcellular_location:Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). .

Other_name:IRF3; Interferon regulatory factor 3; IRF-3

Background:This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],