IPO4 Antibody - Cat. #: CSB-PA575590

SKU: CSB-PA575590

Size :50ul

Clone Number:

Aliases:Imp4 antibody; Imp4b antibody; Importin 4 antibody; Importin 4b antibody; Importin-4 antibody; Importin-4b antibody; Ipo4 antibody; IPO4_HUMAN antibody; Ran binding protein 4 antibody; Ran-binding protein 4 antibody; RanBP4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8TEX9

Immunogen:Fusion protein of Human IPO4

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200

Background:Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IPO4

Research Areas:Epigenetics and Nuclear Signaling;Signal transduction