InVivoMAb Anti-Human CD279/PDCD1/PD1 Antibody (D12)

SKU: HS870010

Size:100ug

Description:D12 is a fully human monoclonal antibody targeting PD-1, isolated from the synthetic AMG phage display library. It binds a novel epitope on PD-1 and induces an unusual conformational change at the receptor’s N-terminus. Despite limited overlap with the natural ligand-binding site, D12 effectively blocks PD-1 interaction with PD-L1 and PD-L2 through steric hindrance. The antibody shows high-affinity binding, recognizes PD-1 on activated human T cells, and cross-reacts with Cynomolgus monkey PD-1.

Host species:Mouse

Species reactivity:Human

Form:Liquid

Storage buffer:0.01M PBS, pH 7.4.

Purity:>95% as determined by SDS-PAGE.

Clonality:Monoclonal

Isotype:IgG2a

Applications:ELISA, Neutralization

Target:Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279

Purification:Protein A/G purified from cell culture supernatant.

Endotoxin level:Please contact us for this information.

Accession:Q15116

Stability and Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID:D12

Product Usage Information:

Predicted molecular weight:

Note:For research use only. Not suitable for clinical or therapeutic use.