INPP5D Polyclonal Antibody

SKU: E-AB-70200

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:INPP5D

Target Synonym:Inositol polyphosphate 5 phosphatase of 145kDa;4;5-trisphosphate 5-phosphatase 1;hp51CN;Inositol polyphosphate 5 phosphatase 145kDa;Inositol polyphosphate 5 phosphatase;Inositol polyphosphate-5-phosphatase of 145 kDa;INPP5D;MGC104855;MGC142140;MGC142142;p150Ship;Phosphatidylinositol 3;4;5 trisphosphate 5 phosphatase 1;Phosphatidylinositol-3;SH2 containing inositol phosphatase isoform b;SH2 domain containing inositol 5' phosphatase 1;SH2 domain containing inositol phosphatase 1;SH2 domain-containing inositol phosphatase 1;SH2 domain-containing inositol-5''-phosphatase 1;SHIP-1;SHIP1;SHIP1;Signaling inositol polyphosphate 5 phosphatase SIP 145;SIP-145;SIP145

Research Areas:Cancer;Immunology;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q9ES52,P97573

Accession:

Background:This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.

Concentration:430 μg/mL

Immunogen:KLH conjugated Synthetic peptide corresponding to Mouse SHIP1

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Affinity purification

Dilution:IHC 1:200-1:1000

Calculated MW:

ObservedMW: