INPP5D Antibody - Cat. #: CSB-PA284759

SKU: CSB-PA284759

Size :100ul

Clone Number:

Aliases:Inositol polyphosphate 5 phosphatase of 145kDa antibody; 4 antibody; 5-trisphosphate 5-phosphatase 1 antibody; hp51CN antibody; Inositol polyphosphate 5 phosphatase 145kDa antibody; Inositol polyphosphate 5 phosphatase antibody; Inositol polyphosphate-5-phosphatase of 145 kDa antibody; INPP5D antibody; MGC104855 antibody; MGC142140 antibody; MGC142142 antibody; p150Ship antibody; Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody; Phosphatidylinositol-3 antibody; SH2 containing inositol phosphatase isoform b antibody; SH2 domain containing inositol 5' phosphatase 1 antibody; SH2 domain containing inositol phosphatase 1 antibody; SH2 domain-containing inositol phosphatase 1 antibody; SH2 domain-containing inositol-5''-phosphatase 1 antibody; SHIP antibody; SHIP-1 antibody; SHIP1 antibody; SHIP1_HUMAN antibody; Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody; SIP-145 antibody; SIP145 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q92835

Immunogen:Synthesized peptide derived from Human SHIP.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

Chuanlei Wang, Journal of Environmental & Engineering Geophysics, Jun 2006; 11: 123 - 131.
Marielle Christiansen, Transportation Science, Feb 2004; 38: 1 - 18.
Paul Weimer, AAPG Bulletin, May 1998; 82: 878 - 917.
Lewis E. Hunter, Geological Society, Lo

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:INPP5D

Research Areas:Immunology;Signal transduction