IL12B Polyclonal Antibody

SKU: E-AB-19816

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: IL12B

Target Synonym: CLMF;CLMF p40;CLMF2;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL 12B;IL-12 subunit p40;IL-12B;IL12 p40;IL12B;IL12B;IMD28;IMD29;Interleukin 12 beta chain;Interleukin 12 p40;Interleukin-12 subunit beta;NK cell stimulatory factor chain 2;NKSF;NKSF2

Research Areas: Cancer;Immunology

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P29460

Accession:

Background: Interleukin-12 (IL-12),is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit (IL-12A p35) and a 40 kDa subunit (IL-12B p40) that is secreted by a wide variety of antigen presenting cells (APCs),including phagocytes,B cells and Langerhans cells. IL-12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12B was observed in the central nervous system of patients with multiple sclerosis (MS),suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12B has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Concentration: 1.32 mg/mL

Immunogen: Synthetic peptide of human IL12B

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:40-1:200

Calculated MW:

ObservedMW: