IFNLR1 Antibody - Cat. #: CSB-PA816871ESR1HU

SKU: CSB-PA816871ESR1HU

Size :50ul

Clone Number:

Aliases:IFNLR1 antibody; IL28RA antibody; LICR2 antibody; Interferon lambda receptor 1 antibody; IFN-lambda receptor 1 antibody; IFN-lambda-R1 antibody; Cytokine receptor class-II member 12 antibody; Cytokine receptor family 2 member 12 antibody; CRF2-12 antibody; Interleukin-28 receptor subunit alpha antibody; IL-28 receptor subunit alpha antibody; IL-28R-alpha antibody; IL-28RA antibody; Likely interleukin or cytokine receptor 2 antibody; LICR2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8IU57

Immunogen:Recombinant Human Interferon lambda receptor 1 protein (21-228AA)

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background:The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IFNLR1

Research Areas:Immunology