ICAM1 Monoclonal Antibody

SKU: BT-MCA2619

Size:100μL

Background:ICAM1 is a 85-110 kDa single chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils), with lower levels that increase in inflammation. ICAM1 is also detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.

Research_area:Immunology

Target_protein:ICAM1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:6G12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ICAM1

Immunogen:Purified recombinant fragment of human ICAM1(28-480aa) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):57.8kDa

UniProt accession:P05362

Synonyms:BB2, CD54, P3.58, ICAM1

GeneID:3383