Human UDP Glucose Ceramide Glucosyltransferase,UGCG ELISA KIT

SKU: E0738Hu

Size:96 Tests-1 Kit

Background:Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (PubMed:8643456, PubMed:1532799). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (PubMed:8643456). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction. They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity). {ECO:0000250|UniProtKB:O88693, ECO:0000269|PubMed:1532799, ECO:0000269|PubMed:8643456, ECO:0000303|PubMed:8643456}.

Research_area:

Applications:ELISA

Target_protein:UGCG

Reactivity:Human

Assay type:Sandwich

Sensitivity:16.88pg/ml

Detection range:37.5-2400pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:UDP Glucose Ceramide Glucosyltransferase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q16739

MASS(Da):44854

GeneID:7357

Synonyms:UGCG

Gene names:UGCG

Standard solution:4800pg/ml