Human Ubiquitin-like Protein Atg12, ATG12 ELISA Kit

SKU: E6380Hu

Size:96 Tests-1 Kit

Background:Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601).

Research_area:Cell Biology

Applications:ELISA

Target_protein:ATG12

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.62ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ubiquitin-like protein ATG12

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O94817

MASS(Da):15,113

GeneID:9140

Synonyms:APG12;APG12L;APG12-like;ATG12;Autophagy-related protein 12;FBR93;HAPG12;Ubiquitin-like protein ATG12

Gene names:ATG12

Standard solution:3200ng/L