Human Tyrosine Protein Phosphatase Non-receptor Type 11, PTPN11 ELISA Kit

SKU: E2445Hu

Size:96 Tests-1 Kit

Background:Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:PTPN11

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.61ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tyrosine protein phosphatase non-receptor type 11

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q06124

MASS(Da):68,011

GeneID:5781

Synonyms:BPTP3;CFC;JMML;NS1;Protein-tyrosine phosphatase 1D;Protein-tyrosine phosphatase 2C;PTP-1D;PTP2C;PTP-2C;PTPN11;SHP2;SHP-2;SH-PTP2;SH-PTP3;Tyrosine-protein phosphatase non-receptor type 11

Gene names:PTPN11

Standard solution:4000ng/L