Human Tripartite Motif-containing Protein 72, TRIM72 ELISA Kit

SKU: E6322Hu

Size:96 Tests-1 Kit

Background:Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca2+-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

Research_area:Signal Transduction; Cell Biology

Applications:ELISA

Target_protein:TRIM72

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.31ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tripartite motif-containing protein 72

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q6ZMU5

MASS(Da):52,731

GeneID:493829

Synonyms:MG53;Mitsugumin-53;TRIM72;Tripartite motif-containing protein 72

Gene names:TRIM72

Standard solution:3200ng/L