Human TNFRSF21/DR6 ELISA Kit PicoKine®

SKU: EK2004

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TNFRSF21

Specificity: Natural and recombinant human TNFRSF21

Background: Death receptor 6 (DR6), also known as tumor necrosis factor receptor superfamily member 21 (TNFRSF21), is a cell surface receptor of the tumor necrosis factor receptor superfamily which activates the JNK and NF-κB pathways. This gene is mapped to 6p12.3. This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q42-H349

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Uniprot ID: O75509

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 27242

Protein Name: Tumor necrosis factor receptor superfamily member 21

Gene Full Name: TNF receptor superfamily member 21

Synonyms: TNF receptor superfamily member 21; BM-018; CD358; DR6; TNFRSF21