Human Tnf Receptor-associated Factor 2, TRAF2 ELISA Kit

SKU: E3268Hu

Size:96 Tests-1 Kit

Background:Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Research_area:Cell Biology

Applications:ELISA

Target_protein:TRAF2

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.28ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tnf Receptor-Associated Factor 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q12933

MASS(Da):55,859

GeneID:7186

Synonyms:E3 ubiquitin-protein ligase TRAF2;RING-type E3 ubiquitin transferase TRAF2;TNF receptor-associated factor 2;TRAF 2;TRAF2;Tumor necrosis factor type 2 receptor-associated protein 3

Gene names:TRAF2

Standard solution:6400ng/L