Human Thiopurine S-methyltransferase, TPMT ELISA Kit

SKU: E6266Hu

Size:96 Tests-1 Kit

Background:Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.

Research_area:Signal Transduction; Metabolism

Applications:ELISA

Target_protein:TPMT

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.29mU/mL

Detection range:0.5-200mU/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Thiopurine S-methyltransferase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P51580

MASS(Da):28,180

GeneID:7172

Synonyms:Thiopurine methyltransferase;Thiopurine S-methyltransferase;TPMT;TPMTD

Gene names:TPMT

Standard solution:240mU/mL