Human Thiopurine methyltranferase,TPMT ELISA KIT

SKU: E6716Hu

Size:96 Tests-1 Kit

Background:Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. {ECO:0000269|PubMed:18484748, ECO:0000269|PubMed:657528, ECO:0000305}.

Research_area:

Applications:ELISA

Target_protein:TPMT

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.018ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Thiopurine methyltranferase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P51580

MASS(Da):28180

GeneID:7172

Synonyms:TPMT

Gene names:TPMT

Standard solution:16ng/ml