Human Telomerase Reverse Transcriptase, TERT ELISA Kit

SKU: E3294Hu

Size:96 Tests-1 Kit

Background:Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

Research_area:Others

Applications:ELISA

Target_protein:TERT

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.54ng/mL

Detection range:3-900ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Telomerase reverse transcriptase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O14746

MASS(Da):126,997

GeneID:7015

Synonyms:CMM9;DKCB4;EST2;hEST2;hTRT;PFBMFT1;TCS1;Telomerase catalytic subunit;Telomerase reverse transcriptase;Telomerase-associated protein 2;TERT;TP2;TRT;

Gene names:TERT

Standard solution:960ng/mL