Human T-cell Surface Glycoprotein Cd3 Zeta Chain, CD247 ELISA Kit

SKU: E3332Hu

Size:96 Tests-1 Kit

Background:Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:CD247

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.026ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:T-cell surface glycoprotein CD3 zeta chain

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P20963

MASS(Da):18,696

GeneID:919

Synonyms:CD antigen CD247;CD247;CD3H;CD3Q;CD3Z;IMD25;T3Z;T-cell receptor T3 zeta chain;T-cell surface glycoprotein CD3 zeta chain;TCRZ

Gene names:CD247

Standard solution:24ng/ml